WebmTORC1 如何调控自噬呢？. 1、研究表明，mTORC1 通过磷酸化使形成的自噬调节复合物 (由 ULK1 和其互作蛋白 Atg13、FIP200、Atg101 等形成) 失活，从而影响自噬小体的生物发生。. 在营养丰富的条件下 ，mTORC1 … WebJan 12, 2024 · 自噬的启动需要ulk1激酶复合物，该复合物由ampk和mtor分别作为激活剂和抑制剂紧密调控。ampk通过磷酸化激活ulk1。由包含fip200、atg13和atg101的ulk1复合物刺激iii类磷脂酰肌醇3-激酶（pik3c3）复合物，该复合物由becn1（可被bcl-2抑制）、ambra1、atg14l、vps15和vps34组成。随后，该复合物产生大量磷脂酰肌醇3 ...
CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for …
WebFIP200 (focal adhesion kinase family interacting protein of 200 kD) is a newly identified essential autophagy gene and a component of the ULK-Atg13-FIP200 complex. We … WebOct 15, 2024 · ULK1, as part of the autophagy pre-initiation complex with FIP200, ATG13 and ATG101 6, activates the downstream autophagy initiation complex through phosphorylation of Beclin1 and ATG14 7,8, in ... richard shaw state farm
Autophagosome biogenesis comes out of the black box - Nature
WebMay 5, 2008 · FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. Autophagy is a membrane-mediated intracellular degradation system. … WebJan 22, 2024 · Bound FIP200 was detected by indirect immunodetection. Peptide sequences corresponding to binding regions A–C are shown below the array. (B and C) HEK293 cells were transfected with FLAG-FIP200 and indicated myc-tagged deletions or truncations of CCPG1 NTD prior to anti-myc immunoprecipitation and immunoblotting … WebMar 16, 2024 · 综上所述，该团队的研究工作首次揭示了一种普遍的、可受磷酸化调控的自噬受体蛋白结合FIP200 Claw结构域来招募自噬起始ULK复合物的新机制，对进一步理解自 … richard shaw tinley park il