Incidence of rhabdomyolysis with daptomycin

Author: ccsl

August undefined, 2024

WebRhabdomyolysis is a well-known clinical syndrome of muscle injury associated with myoglobinuria, electrolyte abnormalities, and often acute kidney injury (AKI). The pathophysiology involves injury to the myocyte membrane and/or altered energy production that results in increased intracellular calcium concentrations and initiation of destructive … WebDaptomycin has been associated with raised creatine kinase activity, with a reported incidence of 2.8% in phase III clinical trials (167 A). Rhabdomyolysis has also been described (168 A ) . A 45-year-old woman with refractory acute myeloid leukemia was given intravenous daptomycin 550 mg (6 mg/kg) every 24 hours because of bacteremia due to ...

Rhabdomyolysis - ScienceDirect

http://cid.oxfordjournals.org/content/42/12/e108.full#:~:text=To%20our%20knowledge%2C%20this%20is%20the%20first%20documented,0.2%25%20of%20the%20study%20population%20reported%20myopathy%20%5B2%5D. WebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting Daptomycin treatment and more frequent monitoring in patients with additional risks, including renal … philips 23001a

These highlights do not include all the information needed to use ...

WebApr 16, 2024 · Background: Daptomycin-associated myopathy has been identified in 2-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are... WebRhabdomyolysis has been reported in up to 5 percent of treated patients receiving daptomycin . Factors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … philips 22 rh 802

Statin use increases risk of daptomycin-related rhabdomyolysis

WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against … WebOne patient had no symptoms but elevated CPK levels on day 9; the other experienced pain and weakness on day 10. The overall incidence of CPK elevations was 2.1% in the daptomycin group and 1.4% in the control group, a statistically insignificant difference. philips 234 deluxe headsetWebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul- trust for america\u0027s health

"WebAug 1, 2024 · Its exact incidence is difficult to determine because of the lack of prospective studies and underreporting of many mild cases [3]. The disease appears more frequent amongst males, African-Americans, those aged <10 and >60 years old, and in persons with body mass index >40 kg/m 2 [4]. " - Incidence of rhabdomyolysis with daptomycin

Incidence of rhabdomyolysis with daptomycin

GUIDELINES FOR TREATMENT OF BONE AND JOINT …

WebJul 1, 2006 · PDF The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III... Find, read and cite all the research you need ... WebThe incidence of rhabdomyolysis (defined as myopathy with a CK >40 times ULN) in patients on 80 mg/day was approximately 0.4% compared with 0% for patients on 20 mg/day. The incidence of myopathy, including rhabdomyolysis, was highest during the first year and then notably decreased during the subsequent years of treatment. ... 7.8 …

Did you know?

WebSep 29, 2024 · Introduction. Daptomycin is a lipopeptide antibiotic often used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). Despite its clinical utility, there have been a few reports of rhabdomyolysis related to daptomycin use [1,2].In this report, we present a case of rhabdomyolysis, severe hyperkalemia, and acute kidney injury … WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal failure. Therefore weekly monitoring of creatine phosphokinase (CPK) levels is …

WebDec 13, 2024 · Conclusion The combined use of daptomycin and statins were significant risk factors for the incidence of CPK elevation defined as levels ≥ULN or ≥5× ULN and rhabdomyolysis. COMPETING INTERESTS The authors declare that they do not have any … WebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio [OR] 3.83; 95% CI 1.43, 10.26) but had no significant effect on the incidence of DAP-related …

WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received … WebThe incidence of myopathy and rhabdomyolysis were highest during the first year and then decreased during the subsequent years of treatment. In another clinical outcomes study in which 10,269 adult patients were treated with simvastatin 40 mg per day (mean follow-up …

WebJun 1, 2014 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI 1.81-74.37, p=0.01, I2 =0%).

Webclinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses. Here, we present a case of a patient with rhabdomyolysis preceded by hyperkalemia philips 236851WebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to fungi, mycobacteria, or Actinomyces require longer durations of therapy – trust for america\u0027s health tfahWebSep 29, 2024 · Daptomycin use is a known cause of rhabdomyolysis; its role in liver injury is less certain. We report a case of daptomycin-induced rhabdomyolysis with liver injury. trust for america healthWebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp [ 1,2 ]. trust for business purposesWebincidence of 2.8% in phase III clinical trials. CASE PRESENTATION: We report the case of 70 years old male patient ... Daptomycin induced rhabdomyolysis is a known possible complication and warrants high level of awareness due to life-threatening potential. … trust for bank accountWebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing. Prior elevations in serum CPK levels and/or myopathy have generally occurred at least 7 days after the initiation of therapy. trust force srlWebJan 24, 2024 · Forest plots of incidence rates of elevated creatine phosphokinase (CPK) and rhabdomyolysis in patients treated with different daptomycin doses. (A) Forest plot showing the comparison of incidence rates of elevated CPK between the SD and HD groups. (B) Forest plot showing the comparison of rhabdomyolysis incidence between the SD and … trust for an impersonal purpose