WebWestern blot analysis of SMAD2/SMAD3 in C2C12 cells (25 µg per lane). Samples were incubated in Phospho-Smad2-S465/467+Smad3-S423/425 polyclonal antibody ( Product … WebSMAD3 belongs to the SMAD family of proteins. They are similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
Luspatercept restores SDF-1-mediated hematopoietic support by MDS …
WebJul 28, 2005 · Compared to normal skin, keloids expressed high basal levels of TGFβR1 and TGFβR2, Smad2, 3 and 4 and phospho-Smad2. Upregulation of TGFβR1 and TGFβR2, Smad3 and p-Smad2 was observed in KF co-cultured with KK, together with enhanced Smad3 phosphorylation and Smad2/3/4 binding complex production. WebAug 6, 2012 · Ligand binding induced signal transduction through this receptor complex results in receptor mediated (R-) smad2 and/or smad3 phosphorylation. This phosphorylation at the C-terminal SSXS motif of smad2/3 allows them to complex with the common mediator (Co-) smad4 [3], [4], translocate into the nucleus, and regulate target … impetuous imp perry mason
Human Phospho-Smad2/3 (S465/S467) Antibody - Bio-Techne
WebDec 12, 2016 · It could be seen that activation of Smad2/3 was involved in EMT induced by EGF using a phospho-Smad2 inhibitor (SB203580) and Smad2/3 siRNA transfection. Although SB203580 is known as an inhibitor of p38 MAP kinase, some breast cancer studies using MDA-MB-231 cells have reported that the p38 MAP kinase pathway appears to be a … WebRabbit polyclonal Smad2 + Smad3 (phospho T8) antibody. Validated in WB and tested in Mouse, Human. Cited in 5 publication(s). Immunogen corresponding to synthetic peptide. WebSmad2/3 phosphorylated at S465/S467 and S423/S425 was detected in immersion fixed Mv1Lu mink lung epithelial cell line treated with 10 ng/mL of Recombinant Human TGF-beta 2 (Catalog # 302-B2) using Rabbit Anti-Human Phospho-Smad2 (S465/S467)/ Smad3 (S423/S425) Polyclonal Antibody (Catalog # AB3226) at 1:50-1:100 dilution for 3 hours at … impetuous type crossword