WebNov 14, 2024 · The protein structure and integrated stress response of HRI in erythropoiesis. (A) Heme and kinase domains of HRI. The 2 heme-binding domains in the N terminus and … WebR-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency; ... Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin. 1 publication. Gene expression databases. Bgee. ENSG00000128965 Expressed in gastrocnemius and 146 other tissues;
EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 ...
WebResponse of EIF2AK1 (HRI) to heme deficiency Pathway in Response of EIF2AK1 (HRI) to heme deficiency SuperPath Genes in the Response of EIF2AK1 (HRI) to heme deficiency Pathway ASNS: ATF3: ATF4: ATF5: CEBPB: CEBPG: CHAC1: DDIT3: EIF2AK1: EIF2S1: EIF2S2: EIF2S3: GRB10: PPP1R15A: TRIB3: STRING image for ... WebMar 30, 2024 · The analysis of BP and pathways of core-DEGs by Metascape show that these 19 core-DEGs are mainly involved in cellular responses to stress, response of eukaryotic translation initiation factor 2 alpha kinase 1 (EIF2AK1)/heme-regulated inhibitor (HRI) to heme deficiency, response to nutrient levels, cellular response to chemical … marwick 21 thermostatic mixer
EIF2AK1 - Wikipedia
WebFunction [ edit] EIF2AK1 inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, … WebFeb 16, 2024 · Mechanistically, DHA disrupts the interaction between heme and the eIF2α kinase heme regulated inhibitor (HRI) triggering the integrated stress response. Genetic ablation of Eif2ak1, which ... WebFeb 7, 2011 · In this report, we examined whether p50(cdc37) is required for the biogenesis of the heme-regulated eIF2 alpha kinase (HRI) in reticulocyte lysate. p50(cdc37) … mar white